Tadalafil is sold under the brand Cialis. It is a potent phosphodiesterase 5 (PDE-5) inhibitor. The advantages of Tadalafil over other PDE-5 inhibitors is that it has a long half-life of 17.5 hours that results in longer duration of action. This drug was approved for sale in United States on 21st November 2003 by Food and Drug Administration (FDA) for treatment of Erectile Dysfunction (ED).
It is the third ED prescription medicine after Sildenafil citrate (Viagra) and Vardenafil (Levitra) for treating ED. It is a non-habit forming drug.
It was approved in October 2011 by the U.S. Food and Drug Administration (FDA) for treating the signs and symptoms of benign prostatic hyperplasia (BPH) as well as a combination of BPH and erectile dysfunction when both conditions co-exist.
How does it function?
Tadalafil inhibits theTadalafil online PDE-5 enzyme, thus preventing the degradation of enzyme cGMP. This causes an increase in the levels of cGMP enzyme, which is responsible for relaxation of smooth muscles and dilation of blood vessels inside the penile region. The dilated blood vessels allow more amount of blood to enter the penile region. This results in strong and firm erection of the penile organ giving complete sexual satisfaction and pleasure.
Effect of Tadalafil in men suffering from lower urinary tract symptoms and erectile dysfunction
A study reported that daily once a day dose of Tadalafil helped men with erectile dysfunction and moderate to severe urinary tract symptoms due to an enlarged prostate. This study included 281 men, 81% of which were sexually active and their age was below 60.
These men suffered from moderate to severely enlarged prostate and thus had urinary problems and 68% of the sexually active men had a medical history of erectile dysfunction. After 12 weeks, men who started taking 5 mg Tadalafil and took up to 20 mg of Tadalafil had an improved erectile function and lower urinary tract symptoms.
What precautions need to be taken while administering this medicine?
- Do not give this medicine to men below 18 years of age.
- Do not give this medicine to a person with history of allergy to Tadalafil or any other PDE-5 inhibitor, do not take this medicine.
- Avoid concomitant use of this medication with drugs like nitrates, alpha-blockers or blood pressure lowering medicines.
- Do not consume alcohol and grape fruit juice while on treatment with this medication.
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Common side effects
The most common side effects of Tadalafil include nausea, headache, dizziness, nasal congestion, and skin rashes. However, these side effects are mild and they often subside after the drug eliminates from the body.